Department of Neurological Sciences, University of Naples, Federico II, Naples, Italy.
Neurol Sci. 2012 Jun;33(3):689-94. doi: 10.1007/s10072-011-0826-7. Epub 2011 Nov 3.
Sleep disturbances are common in patients with Parkinson's disease (PD). We aimed to evaluate prevalence and severity of nighttime sleep disturbances in Italian PD patients and to validate the Italian version of the Parkinson's disease sleep scale. A total of 221 PD patients and 57 healthy controls participated in a cross-sectional study with retest. PDSS, Epworth Sleepiness Scale (ESS), Hamilton Depression Rating Scale, Unified Parkinson's Disease Rating Scale (UPDRS), and Hoehn and Yahr staging were applied. PDSS total and individual items scores from patients were significantly lower than those in controls. Internal consistency of PDSS scale was satisfactory and intraclass correlation coefficient for test-retest reliability was 0.96 for total PDSS score. A significant negative correlation was found between total PDSS and ESS scores, and between total PDSS and HDRS scores. PDSS scores were also related to UPDRS sections II, III and IV, and H&Y stage. PDSS and ESS scores were not related to levodopa equivalent dose. Daytime sleepiness, depressive symptoms and disease severity correlate with sleep disturbances in Italian PD patients. The PDSS is a valid and reliable tool to evaluate sleep disturbances in Italian patients.
睡眠障碍在帕金森病（PD）患者中很常见。我们旨在评估意大利 PD 患者夜间睡眠障碍的患病率和严重程度，并验证帕金森病睡眠量表的意大利语版本。共有 221 名 PD 患者和 57 名健康对照者参与了一项具有复测的横断面研究。应用 PDSS、Epworth 嗜睡量表（ESS）、汉密尔顿抑郁评定量表、统一帕金森病评定量表（UPDRS）和 Hoehn 和 Yahr 分期。与对照组相比，患者的 PDSS 总分和个别项目得分明显较低。PDSS 量表的内部一致性令人满意，总 PDSS 评分的组内相关系数为 0.96。总 PDSS 评分与 ESS 评分之间以及总 PDSS 评分与 HDRS 评分之间存在显著负相关。PDSS 评分还与 UPDRS 第二、三、四部分和 H&Y 分期相关。PDSS 和 ESS 评分与左旋多巴等效剂量无关。日间嗜睡、抑郁症状和疾病严重程度与意大利 PD 患者的睡眠障碍相关。PDSS 是评估意大利患者睡眠障碍的有效且可靠的工具。
