Abe Kazuo, Hikita Tachio, Sakoda Sabro
Department of Neurology, Osaka University Graduate School of Medicine, D-4, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
J Neurol Sci. 2005 Jul 15;234(1-2):73-8. doi: 10.1016/j.jns.2005.03.036.
Sleep disorders are common in the general population and occur more frequently with advancing age. However, patients with Parkinson's disease (PD) have been known to have various sleep disturbances beyond those to be expected from the effect of aging alone. We tried to quantify the various aspects of nocturnal sleep problems in PD using the PD sleep scale (PDSS). 64 patients with PD and 60 age- and sex-matched controls completed the PDSS. After neurological examinations, we assessed the degree of sleep disorder by the PDSS. We evaluated the severity of PD by the Hoehn and Yahr Scale and the unified PD rating scale (UPDRS). To compare the various aspects of nocturnal sleep problems in PD between in Japan and in the United Kingdom (UK), we referenced and compared our results with those by Chaudhui et al. The PDSS scores in PD group were significantly different from those in controls. Individual items of the scale showed good discriminatory power between PD and controls. Overall tendencies were the same in Japan and in the UK, but there were some different points, especially absence of refreshing quality of sleep in Japan. We believe that the PDSS provides an objective method for targeted therapeutic approaches for the treatment of disturbed sleep in PD even among countries with different cultures, such as Japan and the UK.
睡眠障碍在普通人群中很常见，且随着年龄增长而更频繁地出现。然而，众所周知，帕金森病（PD）患者存在各种睡眠障碍，这些障碍超出了仅由衰老影响所预期的范围。我们试图使用帕金森病睡眠量表（PDSS）对PD患者夜间睡眠问题的各个方面进行量化。64例PD患者和60例年龄及性别匹配的对照完成了PDSS评估。经过神经系统检查后，我们通过PDSS评估睡眠障碍程度。我们通过Hoehn和Yahr量表以及统一帕金森病评定量表（UPDRS）评估PD的严重程度。为了比较日本和英国PD患者夜间睡眠问题的各个方面，我们将我们的结果与Chaudhui等人的结果进行了参考和比较。PD组的PDSS评分与对照组有显著差异。该量表的各个项目在PD患者和对照组之间显示出良好的区分能力。日本和英国的总体趋势相同，但存在一些不同点，尤其是日本患者睡眠缺乏恢复精力的质量。我们认为，即使在日本和英国等具有不同文化的国家，PDSS也为针对PD患者睡眠障碍的靶向治疗方法提供了一种客观的方法。
