National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA.
Sci Transl Med. 2011 Nov 2;3(107):107ps43. doi: 10.1126/scitranslmed.3003278.
In a mouse model, chronic nicotine exposure before cocaine use exacerbated the epigenetic, gene-expression, electrophysiological, and behavioral effects that occur during the transition from acute to chronic responses to cocaine that have been linked with the addictive process. Nicotine enhancement of the effects can be mimicked with an inhibitor of chromatin-modifying enzymes (class I and II histone deacetylases). These findings may spur the discovery of therapeutics for the treatment of addiction.
在小鼠模型中，可卡因使用前的慢性尼古丁暴露加剧了从急性到慢性可卡因反应的转变过程中发生的表观遗传、基因表达、电生理和行为效应，这些效应与成瘾过程有关。染色质修饰酶（I 类和 II 类组蛋白去乙酰化酶）抑制剂可以模拟尼古丁对这些效应的增强作用。这些发现可能会促进治疗成瘾的疗法的发现。
