Bobrik I I, Davidenko L M, Furmanenko E D
Vrach Delo. 1990 Jun(6):63-6.
In the differentiation of A-insulocytes in the human pancreas the following stages were distinguished: nondifferentiated cells of the epithelial anlage (5-6 weeks)--cell of primary duct (5-6 weeks)--duct cell containing lumps of secretory material (7-8 weeks)--cell precursor of A-insulocyte containing immature secretory granules (7-8 weeks)--A-insulocyte containing separate mature granules (9-10 weeks)--mature A-insulocyte (9-10 weeks). All this is accompanied by appearance at the 7-8 week of glucagon in the pancreatic tissue (76.20 +/- 17.28 ng/mg of wet tissue). The content of glucagon rises in 9-10 weeks 8.3 times.
在人类胰腺中A胰岛细胞的分化过程中，区分出了以下阶段：上皮原基的未分化细胞（5 - 6周）——初级导管细胞（5 - 6周）——含有分泌物质团块的导管细胞（7 - 8周）——含有未成熟分泌颗粒的A胰岛细胞前体细胞（7 - 8周）——含有分散成熟颗粒的A胰岛细胞（9 - 10周）——成熟的A胰岛细胞（9 - 10周）。所有这些过程伴随着胰腺组织中胰高血糖素在7 - 8周时出现（76.20±17.28纳克/毫克湿组织）。胰高血糖素的含量在9 - 10周时上升8.3倍。
