Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Int Rev Neurobiol. 2011;101:169-201. doi: 10.1016/B978-0-12-387718-5.00007-9.
A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.
过去 20 多年来的大量出版物表明，精神分裂症和心境障碍患者的免疫系统功能发生了改变。本章回顾了相关证据，这些证据表明细胞因子网络的促炎状态会引发精神病理症状，并且可能与这些主要精神疾病的发病机制和病理生理学有关。作者还介绍了最近的数据，这些数据将免疫激活与目前关于激活免疫细胞影响大脑功能的理论联系起来。他们还关注环境在免疫激活中的作用以及微生物组和肠道菌群的作用。对这些因素的深入了解有助于开发新的治疗策略和改善精神障碍的临床管理。
