Bair Brooke, Fivenson David
Saint Joseph Mercy Health System, Dermatology Residency Program, Ann Arbor, MI, USA.
J Drugs Dermatol. 2011 Sep;10(9):1042-4.
Calcinosis cutis is a term used to describe a group of disorders which result in calcium deposits in the skin. These disorders can be separated based on etiology.
Sodium thiosulfate has been used to systemically treat calciphylaxis with little to no adverse effects. We report two cases of ulcerative calcinosis cutis which were refractory to multiple topical treatments and did not improve with correction of underlying electrolyte abnormalities.
Both cases showed an excellent response to topical 25% sodium thiosulfate compounded in zinc oxide.
We are limited by a small sample size (n=2) in this case series.
We recommend topical sodium thiosulfate 25% as an alternative treatment for dystrophic calcinosis cutis.
皮肤钙化是一个用于描述导致钙在皮肤中沉积的一组病症的术语。这些病症可根据病因进行分类。
硫代硫酸钠已被用于全身治疗钙化防御，几乎没有不良反应。我们报告了两例溃疡性皮肤钙化病例，这些病例对多种局部治疗均无效，且在纠正潜在的电解质异常后也未改善。
两例病例对局部使用的25%硫代硫酸钠与氧化锌混合制剂均表现出良好反应。
本病例系列样本量较小（n = 2）。
我们推荐局部使用25%硫代硫酸钠作为营养不良性皮肤钙化的替代治疗方法。
