Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Br J Dermatol. 2016 Sep;175(3):608-11. doi: 10.1111/bjd.14412. Epub 2016 Apr 17.
Calcinosis cutis is a chronic calcium-mediated disease that causes significant morbidity. Multiple treatments have been tried, with varying results; indeed, to date, no standard treatment has been generally accepted. Sodium metabisulfite is an inorganic compound that, when it reacts with oxygen, becomes sodium sulfate, a metabolite of sodium thiosulfate that has a similar ability to inhibit calcium oxalate agglomeration. Four women diagnosed with calcinosis cutis, secondary to dermatomyositis, systemic sclerosis and radiodermatitis after breast cancer, were evaluated for their response to topical 25% sodium metabisulfite. In all patients a decrease in lesion size, erythema and pain from injuries was shown, with complete resolution of the associated ulcers. One patient had a complete response. None experienced adverse effects. Topical sodium metabisulfite is a promising emerging therapy that should be considered as a valid alternative treatment in calcinosis cutis. Randomized prospective studies are required to evaluate its true efficacy.
硬皮病相关性钙质沉着症是一种慢性钙介导性疾病，可导致严重的发病率。已经尝试了多种治疗方法，结果各不相同；事实上，迄今为止，尚未普遍接受任何标准治疗方法。亚硫酸氢钠是一种无机化合物，与氧气反应后会变成硫酸钠，是硫代硫酸钠的代谢物，具有类似抑制草酸钙聚集的能力。对四名患有硬皮病相关性钙质沉着症的女性进行了评估，这些女性继发于皮肌炎、系统性硬化症和乳腺癌放射性皮炎，评估了她们对 25%亚硫酸氢钠的局部治疗反应。所有患者的皮损大小、红斑和损伤疼痛均有减轻，相关溃疡完全愈合。一名患者有完全反应。无不良反应。局部亚硫酸氢钠是一种有前途的新兴治疗方法，应被视为硬皮病相关性钙质沉着症的有效替代治疗方法。需要进行随机前瞻性研究来评估其真正的疗效。
