磷酸化c-Src是宫颈鳞状细胞癌患者复发的一种新型预测指标。
Phosphorylated c-Src is a novel predictor for recurrence in cervical squamous cell cancer patients.
作者信息
Hou Teng, Xiao Juan, Zhang Huiting, Gu Haifeng, Feng Yanling, Li Jundong
机构信息
State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, GD 510060, China.
出版信息
Int J Clin Exp Pathol. 2013 May 15;6(6):1121-7. Print 2013.
AIMS
The molecular mechanisms of the tumorigenesis and recurrence of cervical cancer are poorly understood. The objective of this study was to analyze the expression of phosphorylated c-Src (phospho-c-Src) and its clinical significance in human cervical cancer.
METHODS
The expression of phospho-c-Src was determined by immunohistochemistry in a total of 127 cervical specimens including 20 normal cervix tissues, 20 cases of carcinoma in situ of cervix (CIS), and 87 cases of cervical squamous cell carcinoma (CSCC).
RESULTS
The expression of phospho-Src in normal cervix, CIS, and CSCC increased gradually in ascending order (p=0.026). In addition, the expression of phospho-Src was correlated with overall (p=0.037) and recurrence (p=0.001) survival of cervical cancer. In multivariate Cox regression analysis, phospho-Src expression was an independent prognosis factor for recurrence-free survival (p=0.004).
CONCLUSION
Our present study suggests that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker to predict recurrence in CSCC.
目的
宫颈癌发生和复发的分子机制尚不清楚。本研究的目的是分析磷酸化c-Src（phospho-c-Src）在人宫颈癌中的表达及其临床意义。
方法
采用免疫组织化学法检测127例宫颈标本中phospho-c-Src的表达，其中包括20例正常宫颈组织、20例宫颈原位癌（CIS）和87例宫颈鳞状细胞癌（CSCC）。
结果
正常宫颈、CIS和CSCC中phospho-Src的表达呈逐渐升高趋势（p = 0.026）。此外，phospho-Src的表达与宫颈癌的总生存期（p = 0.037）和复发生存期（p = 0.001）相关。多因素Cox回归分析显示，phospho-Src表达是无复发生存的独立预后因素（p = 0.004）。
结论
本研究提示Src信号通路可能在宫颈癌进展中起重要作用。Phospho-Src表达可作为预测CSCC复发的预后标志物。
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