Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi, India.
DNA Cell Biol. 2012 Apr;31(4):636-43. doi: 10.1089/dna.2011.1392. Epub 2011 Nov 4.
In this study, we investigated the association of GSTP1, GSTM1, and GSTP1 genetic variants with renal cell carcinoma (RCC) among North Indian patients. The difference in frequency of the GSTT1 null genotype between cases and control subjects was statistically significant (active ver. null, odds ratio [OR]=0.368; confidence intervals [CI] 95%=0.243-0.557, p=0.001). The differences in the frequency of GSTP1 genotypes were statistically significant (AA ver. AG/GG, OR=1.879; CI 95%=0.355-0.797, p=0.002). Higher allelic frequency of the GSTP1 G allele was associated with RCC cases (G ver. A allele, OR=1.534; 95% CI=1.159-2.030, p=0.003). The gene-gene interaction in terms of three-way combination of GSTM1 null, GSTT1 null, and GSTP1 (AG/GG) resulted in 4.5-fold increase in RCC risk (OR=4.452; 95% CI=2.220-9.294). Similarly, our study revealed that GST polymorphism might be a vital determinant of advancement to higher pathological stages and histological grades of RCC. Our findings suggest that genetic variability in members of the GST gene family may be associated with an increased susceptibility to RCC and its progression.
在这项研究中，我们调查了 GSTP1、GSTM1 和 GSTP1 基因变异与北印度患者肾细胞癌 (RCC) 的关联。病例组和对照组 GSTT1 无效基因型的频率差异具有统计学意义（活跃基因型与无效基因型相比，比值比 [OR]=0.368；95%置信区间 [CI]=0.243-0.557，p=0.001）。GSTP1 基因型的频率差异具有统计学意义（AA 基因型与 AG/GG 基因型相比，OR=1.879；95%CI=0.355-0.797，p=0.002）。GSTP1 G 等位基因的等位基因频率较高与 RCC 病例相关（G 等位基因与 A 等位基因相比，OR=1.534；95%CI=1.159-2.030，p=0.003）。GSTM1 无效、GSTT1 无效和 GSTP1（AG/GG）三种基因型的基因-基因相互作用导致 RCC 风险增加 4.5 倍（OR=4.452；95%CI=2.220-9.294）。同样，我们的研究表明 GST 多态性可能是 RCC 向更高病理分期和组织学分级进展的重要决定因素。我们的研究结果表明，GST 基因家族成员的遗传变异可能与 RCC 的易感性及其进展有关。
