Kessell A E, Finnie J W, Blumbergs P C, Manavis J, Jerrett I V
School of Animal and Veterinary Science, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
J Comp Pathol. 2012 Jul;147(1):62-72. doi: 10.1016/j.jcpa.2011.09.006. Epub 2011 Nov 4.
Neuroaxonal dystrophy (NAD) is a morphological abnormality in man and animals that is characterized by the occurrence of numerous axonal swellings (spheroids) in the nervous system. NAD has been described in Suffolk lambs in the USA, Merino lambs in Australia and several breeds of sheep in New Zealand. This paper describes the clinicopathological changes of only the second occurrence of NAD reported in Merino lambs. There were some features (myelin loss, gliosis and visual impairment) in these Australian cases that have not been reported previously in ovine NAD. Application of immunohistochemical markers of axonal transport suggested that disruption of this transport mechanism contributed to spheroid development.
神经轴索性营养不良（NAD）是人和动物身上的一种形态学异常，其特征是神经系统中出现大量轴突肿胀（球体）。在美国的萨福克羔羊、澳大利亚的美利奴羔羊以及新西兰的几个绵羊品种中都有NAD的报道。本文描述了美利奴羔羊中仅第二次出现的NAD的临床病理变化。这些澳大利亚病例中存在一些特征（髓鞘脱失、胶质细胞增生和视力损害），此前在绵羊NAD中尚未有报道。轴突运输免疫组化标志物的应用表明，这种运输机制的破坏促成了球体的形成。
