Finnie John W, Manavis Jim
SA Pathology, Hanson Institute Centre for Neurological Diseases and Schools of Medicine and Veterinary Science, University of Adelaide, Adelaide, South Australia, Australia.
J Vet Diagn Invest. 2017 Nov;29(6):852-855. doi: 10.1177/1040638717721579. Epub 2017 Jul 28.
Neuroaxonal dystrophy (NAD) is a neurologic disorder of sheep characterized by accumulation of numerous axonal swellings (spheroids) in specific regions of the brainstem and spinal cord. Disruption of axonal transport, which is driven in anterograde and retrograde directions by the molecular motors, kinesin and dynein, respectively, is believed to contribute to spheroid development. Accordingly, we examined spheroids in ovine NAD cases immunohistochemically for kinesin and dynein and found both motor proteins, with dynein more strongly expressed than kinesin. Further investigations of the kinesin and dynein content of axonal spheroids in NAD, and other neurodegenerative disorders of domestic animals, could assist in better understanding the pathogenesis of these diseases.
神经轴突营养不良（NAD）是绵羊的一种神经疾病，其特征是在脑干和脊髓的特定区域积累大量轴突肿胀（球体）。轴突运输分别由分子马达驱动蛋白驱动，顺行方向由驱动蛋白驱动，逆行方向由动力蛋白驱动，轴突运输的破坏被认为是球体形成的原因。因此，我们通过免疫组织化学方法检测了绵羊NAD病例中的球体是否存在驱动蛋白和动力蛋白，结果发现这两种驱动蛋白均存在，且动力蛋白的表达比驱动蛋白更强。对NAD以及家畜其他神经退行性疾病中轴突球体的驱动蛋白和动力蛋白含量进行进一步研究，可能有助于更好地理解这些疾病的发病机制。
