Mehlisch D R, Sollecito W A, Helfrick J F, Leibold D G, Markowitz R, Schow C E, Shultz R, Waite D E
Biomedical Research Group, Austin, TX.
J Am Dent Assoc. 1990 Aug;121(2):257-63. doi: 10.14219/jada.archive.1990.0237.
Pharmacological management of pain for acute and chronic conditions has been guided by a scientific understanding of peripheral and central acting mechanisms for the control of inflammation as well as pain. Oral surgery pain is a reliable model to reference the effectiveness of commonly used analgesics such as ibuprofen and acetaminophen. A total of 706 patients who were experiencing moderate to severe pain received a single dose of ibuprofen, acetaminophen, or placebo. After 6 hours, the degree of pain relief and tolerance was assessed. Ibuprofen has important implications for postoperative pain in clinical practice.
