Department of Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):212-6. doi: 10.1158/1055-9965.EPI-11-0870-T. Epub 2011 Nov 4.
A recent genome-wide association study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study, we attempt to replicate these five loci in a series of nested prostate cancer case-control studies of European ancestry.
We genotyped five single-nucleotide polymorphism (SNP): rs13385191 (chromosome 2p24), rs12653946 (5p15), rs1983891 (6p21), rs339331 (6p22), and rs9600079 (13q22), in 7,956 prostate cancer cases and 8,148 controls from a series of nested case-control studies within the National cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). We tested each SNP for association with prostate cancer risk and assessed whether associations differed with respect to disease severity and age of onset.
Four SNPs (rs13385191, rs12653946, rs1983891, and rs339331) were significantly associated with prostate cancer risk (P values ranging from 0.01 to 1.1 × 10(-5)). Allele frequencies and ORs were overall lower in our population of European descent than in the discovery Asian population. SNP rs13385191 (C2orf43) was only associated with low-stage disease (P = 0.009, case-only test). No other SNP showed association with disease severity or age of onset. We did not replicate the 13q22 SNP, rs9600079 (P = 0.62).
Four SNPs associated with prostate cancer risk in an Asian population are also associated with prostate cancer risk in men of European descent.
This study illustrates the importance of evaluation of prostate cancer risk markers across ethnic groups.
最近一项针对日本人群前列腺癌的全基因组关联研究（GWAS）发现了五个以前在其他种族中未发现的新区域。在这项研究中，我们试图在一系列欧洲血统的巢式前列腺癌病例对照研究中复制这些五个位点。
我们对 7956 例前列腺癌病例和 8148 例对照进行了五个单核苷酸多态性（SNP）的基因分型：rs13385191（2p24）、rs12653946（5p15）、rs1983891（6p21）、rs339331（6p22）和 rs9600079（13q22），这些病例来自美国国立癌症研究所乳腺癌和前列腺癌队列联盟（BPC3）内一系列巢式病例对照研究。我们测试了每个 SNP 与前列腺癌风险的关联，并评估了关联是否与疾病严重程度和发病年龄有关。
四个 SNP（rs13385191、rs12653946、rs1983891 和 rs339331）与前列腺癌风险显著相关（P 值范围从 0.01 到 1.1×10(-5)）。在我们的欧洲血统人群中，等位基因频率和 OR 总体上低于发现的亚洲人群。SNP rs13385191（C2orf43）仅与低分期疾病相关（P = 0.009，仅病例检验）。没有其他 SNP 与疾病严重程度或发病年龄相关。我们没有复制 13q22 SNP rs9600079（P = 0.62）。
与亚洲人群前列腺癌风险相关的四个 SNP 也与欧洲血统男性的前列腺癌风险相关。
这项研究说明了在不同种族群体中评估前列腺癌风险标志物的重要性。
