The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?
作者信息
Hermouet Sylvie, Vilaine Mathias
出版信息
Haematologica. 2011 Nov;96(11):1575-9. doi: 10.3324/haematol.2011.055392.
Abstract
摘要
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The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?JAK2 46/1单倍型：细胞因子刺激下髓单核细胞反应异常的标志物，导致炎症、髓系肿瘤风险增加及抗感染防御功能受损？
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本文引用的文献
1
Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm.野生型JAK2的同源重组，是骨髓增殖性肿瘤发生过程中的一个新的早期步骤。
Blood. 2011 Dec 8;118(24):6468-70. doi: 10.1182/blood-2011-08-372813.
2
The prognostic impact of germline 46/1 haplotype of Janus kinase 2 in cytogenetically normal acute myeloid leukemia.胚系 JAK2 46/1 单倍型对细胞遗传学正常的急性髓系白血病的预后影响。
Haematologica. 2011 Nov;96(11):1613-8. doi: 10.3324/haematol.2011.043885. Epub 2011 Jul 26.
3
The JAK2 46/1 haplotype in splanchnic vein thrombosis.内脏静脉血栓形成中的JAK2 46/1单倍型
Blood. 2011 May 26;117(21):5777-8. doi: 10.1182/blood-2011-03-343657.
4
The JAK2 46/1 haplotype in Budd-Chiari syndrome and portal vein thrombosis.JAK2 46/1 单倍型与布-加综合征和门静脉血栓形成。
Blood. 2011 Apr 14;117(15):3968-73. doi: 10.1182/blood-2010-11-319087. Epub 2011 Mar 1.
5
Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3.原发性血小板增多症和真性红细胞增多症中的炎症与血栓形成：C 反应蛋白和五聚素 3 的不同作用。
Haematologica. 2011 Feb;96(2):315-8. doi: 10.3324/haematol.2010.031070. Epub 2010 Dec 20.
6
Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F.促炎细胞因子肝细胞生长因子和白细胞介素-11 在真性红细胞增多症中过度表达，并独立于 JAK2V617F 促进克隆性红细胞的生长。
Oncogene. 2011 Feb 24;30(8):990-1001. doi: 10.1038/onc.2010.479. Epub 2010 Nov 1.
7
JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia.骨髓增殖性肿瘤和急性髓系白血病中JAK2 46/1单倍型分析
Leukemia. 2010 Oct;24(10):1809-13. doi: 10.1038/leu.2010.172. Epub 2010 Sep 2.
8
In vitro differentiation of bone marrow stromal cells into neurons and glial cells and differential protein expression in a two-compartment bone marrow stromal cell/neuron co-culture system.骨髓基质细胞在双室骨髓基质细胞/神经元共培养系统中向神经元和神经胶质细胞的体外分化及差异蛋白表达。
J Clin Neurosci. 2010 Jul;17(7):908-13. doi: 10.1016/j.jocn.2009.10.013. Epub 2010 Apr 8.
9
The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms.JAK2 46/1 单体型易患 MPL 突变的骨髓增殖性肿瘤。
Blood. 2010 Jun 3;115(22):4517-23. doi: 10.1182/blood-2009-08-236448. Epub 2010 Mar 19.
10
JAK2 mutation and disease phenotype: a double L611V/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1/2 rather than STAT5.JAK2突变与疾病表型：JAK2的顺式双L611V/V617F突变与单纯红细胞增多症以及AKT和ERK1/2的激活增加相关，而非STAT5。
Leukemia. 2010 May;24(5):1069-73. doi: 10.1038/leu.2010.23. Epub 2010 Feb 25.
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