Hematology Department, Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy.
Haematologica. 2011 Feb;96(2):315-8. doi: 10.3324/haematol.2010.031070. Epub 2010 Dec 20.
We tested the hypothesis that levels of pentraxin high sensitivity C-reactive protein and pentraxin 3 might be correlated with cardiovascular complications in patients with essential thrombocythemia and polycythemia vera. High sensitivity C-reactive protein and pentraxin 3 were measured in 244 consecutive essential thrombocythemia and polycythemia vera patients in whom, after a median follow up of 5.3 years (range 0-24), 68 cardiovascular events were diagnosed. The highest C-reactive protein tertile was compared with the lowest (>3 vs. <1 mg/L) and correlated with age (P=0.001), phenotype (polycythemia vera vs. essential thrombocythemia, P=0.006), cardiovascular risk factors (P=0.012) and JAK2V617F allele burden greater than 50% (P=0.003). Major thrombosis rate was higher in the highest C-reactive protein tertile (P=0.01) and lower at the highest pentraxin 3 levels (P=0.045). These associations remained significant in multivariate analyses and indicate that blood levels of high sensitivity C-reactive protein and petraxin 3 independently and in opposite ways modulate the intrinsic risk of cardiovascular events in patients with myeloproliferative disorders.
我们检验了这样一个假设，即高敏 C 反应蛋白和五聚素 3 的水平可能与原发性血小板增多症和真性红细胞增多症患者的心血管并发症有关。在 244 例连续的原发性血小板增多症和真性红细胞增多症患者中测量了高敏 C 反应蛋白和五聚素 3 的水平，这些患者的中位随访时间为 5.3 年（范围 0-24 年），共诊断出 68 例心血管事件。将最高 C 反应蛋白三分位数与最低三分位数（>3 与<1mg/L）进行比较，并与年龄（P=0.001）、表型（真性红细胞增多症与原发性血小板增多症，P=0.006）、心血管危险因素（P=0.012）和 JAK2V617F 等位基因负担>50%（P=0.003）相关。在最高 C 反应蛋白三分位数中，主要血栓形成的发生率更高（P=0.01），而在最高五聚素 3 水平时，发生率更低（P=0.045）。在多变量分析中，这些关联仍然显著，表明高敏 C 反应蛋白和五聚素 3 的血液水平独立且以相反的方式调节骨髓增生性疾病患者心血管事件的固有风险。
