Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.
Pediatr Diabetes. 2012 Jun;13(4):340-3. doi: 10.1111/j.1399-5448.2011.00832.x. Epub 2011 Nov 8.
The "accelerator hypothesis" has made a significant impact on research into the etiology of type 1 diabetes. Some, but not all prospective studies have confirmed a weak association between insulin resistance and faster progression to diabetes among persons with advanced islet autoimmunity. However, there is hardly any evidence that insulin resistance can cause development of islet autoimmunity, thus be responsible for the ongoing pandemic of type 1 diabetes in children.
“加速假说”对 1 型糖尿病病因学的研究产生了重大影响。一些（但不是全部）前瞻性研究证实，在胰岛自身免疫水平较高的人群中，胰岛素抵抗与糖尿病进展较快之间存在较弱的关联。然而，几乎没有证据表明胰岛素抵抗会导致胰岛自身免疫的发展，从而对儿童中 1 型糖尿病的持续流行负责。
