Cox S M, Sherman M L, Leveno K J
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032.
Am J Obstet Gynecol. 1990 Sep;163(3):767-72. doi: 10.1016/0002-9378(90)91065-k.
One hundred fifty-six women with preterm labor between 24 and 34 weeks' gestation were randomized to receive either intravenous magnesium sulfate or no tocolytic therapy. Magnesuim sulfate infusions of up to 3 gm/hr were used in 76 pregnancies and resulted in a mean serum magnesium concentration of 5.5 +/- 1.4 mEq/L (mean +/- SEM). Compared with 80 control pregnancies, magnesium sulfate tocolysis had no significant effect on duration of gestation, birth weight, neonatal morbidity, and perinatal mortality. We conclude that clinically safe infusions of magnesium sulfate are ineffective when used to prevent preterm birth.
156名妊娠24至34周的早产妇女被随机分为两组，一组接受静脉注射硫酸镁，另一组不接受任何宫缩抑制治疗。76例妊娠使用了最高达3克/小时的硫酸镁输注，导致血清镁平均浓度为5.5±1.4毫当量/升（均值±标准误）。与80例对照妊娠相比，硫酸镁宫缩抑制治疗对妊娠持续时间、出生体重、新生儿发病率和围产期死亡率均无显著影响。我们得出结论，临床上安全的硫酸镁输注用于预防早产时无效。
