酸橙花与术前焦虑

Citrus aurantium blossom and preoperative anxiety.

作者信息

Akhlaghi Mahmood, Shabanian Gholamreza, Rafieian-Kopaei Mahmoud, Parvin Neda, Saadat Mitra, Akhlaghi Mohsen

机构信息

Anesthesiology Department, Shahrekord University of Medical Sciences, Shahrekord, Iran.

出版信息

Rev Bras Anestesiol. 2011 Nov-Dec;61(6):702-12. doi: 10.1016/S0034-7094(11)70079-4.

DOI:10.1016/S0034-7094(11)70079-4

PMID:22063371

Abstract

BACKGROUND AND OBJECTIVES

Reducing anxiety is very important before operation. Preoperative visit and use of premedication are popular methods to achieve this goal, but the role of anxiolytic premedication remains unclear and postoperative side-effects may result from routine premedication. Citrus aurantium is used as an alternative medicine in some countries to treat anxiety, and recently the anxiolytic role of this medicinal plant was established in an animal model study. The aim of this study was to assess the anxiolytic effect of Citrus aurantium blossomon preoperative anxiety.

METHODS

We studied 60 ASA I patients undergoing minor operation. In a randomized double-blind design, two groups of 30 patients received one of the following oral premedication two hours before induction of anesthesia: 1) Citrus aurantium blossom distillate 1mL.kg(-1) (C-group); 2) Saline solution 1mL.kg(-1) as placebo (P-group). Anxiety was measured before and after premedication using the Spielberger state-trait anxiety inventory (STAI-state) and the Amsterdam preoperative anxiety and information scale (APAIS) before operation.

RESULTS

After premedication, both the STAI-state and the APAIS scales were decreased in C-group (p<0.05); while exhibiting no significant changes in P-group.

CONCLUSIONS

Citrus aurantium blossom may be effective in terms of reduction in preoperative anxiety before minor operation.

摘要

背景与目的

术前减轻焦虑非常重要。术前访视和使用术前用药是实现这一目标的常用方法，但抗焦虑术前用药的作用仍不明确，常规术前用药可能会导致术后副作用。在一些国家，枳壳被用作治疗焦虑的替代药物，最近在一项动物模型研究中证实了这种药用植物的抗焦虑作用。本研究的目的是评估枳壳花对术前焦虑的抗焦虑作用。

方法

我们研究了60例接受小手术的美国麻醉医师协会（ASA）I级患者。采用随机双盲设计，两组各30例患者在麻醉诱导前两小时接受以下口服术前用药之一：1）枳壳花馏出液1mL·kg⁻¹（C组）；2）1mL·kg⁻¹生理盐水作为安慰剂（P组）。术前使用斯皮尔伯格状态-特质焦虑量表（STAI-状态）和阿姆斯特丹术前焦虑与信息量表（APAIS）在术前用药前后测量焦虑程度。