Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstraße 8, 8010 Graz, Austria.
BioTechMed, Mozartgasse 12, 8010 Graz, Austria.
Nutrients. 2022 May 18;14(10):2111. doi: 10.3390/nu14102111.
Various neurocognitive and mental health-related conditions have been associated with the gut microbiome, implicating a microbiome-gut-brain axis (MGBA). The aim of this systematic review was to identify, categorize, and review clinical evidence supporting medicinal plants for the treatment of mental disorders and studies on their interactions with the gut microbiota.
This review included medicinal plants for which clinical studies on depression, sleeping disorders, anxiety, or cognitive dysfunction as well as scientific evidence of interaction with the gut microbiome were available. The studies were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Eighty-five studies met the inclusion criteria and covered thirty mental health-related medicinal plants with data on interaction with the gut microbiome.
Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways. However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites. Data for , , and indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits. Studies specifically assessing the effects on MGBA-related pathways are still required for most medicinal plants.
各种与神经认知和心理健康相关的病症都与肠道微生物群有关，这暗示了一个微生物群-肠道-大脑轴（MGBA）的存在。本系统综述的目的是确定、分类和综述支持药用植物治疗精神障碍的临床证据，以及研究它们与肠道微生物群相互作用的证据。
本综述纳入了有治疗抑郁症、睡眠障碍、焦虑或认知功能障碍的临床研究以及与肠道微生物群相互作用的科学证据的药用植物。研究报告使用了系统评价和荟萃分析的首选报告项目（PRISMA）声明。
85 项研究符合纳入标准，涵盖了 30 种与心理健康相关的药用植物，并有关于与肠道微生物群相互作用的数据。
只有少数研究专门设计用于评估草药制剂如何影响 MGBA 相关的靶点或途径。然而，许多研究提供了与 MGBA 可能相互作用的线索，例如有益微生物的丰度增加、抗炎作用，或肠道微生物代谢物对 MGBA 相关途径的影响。、和的数据表明，其成分与肠道微生物群的相互作用可能介导了心理健康的益处。对于大多数药用植物，仍需要进行专门评估对 MGBA 相关途径影响的研究。
