Sánchez-Vargas M C, López-Ortiz O, Bustamante-Hernández A
Dirección General de Epidemiología, México.
Bol Med Hosp Infant Mex. 1990 Jul;47(7):489-94.
A measles outbreak that involved 230 cases occurred in 1988 in Santiago Yaitepec, Oaxaca, had an attack rate of 14% and a case-fatality ratio of 3.9%. That community is relatively speaking isolated. A pre-outbreak measles vaccine coverage of 38.7% was found among children 1-15 years old. We compared attack rates among vaccines and non-vaccines and adjusted the figures for age and source of vaccine information. The vaccine efficacy based on this comparison was 72%. We classified cases as primary and secondary for household level. The secondary attack rate was 15.5%. The comparison based on secondary attack rates yield an estimate of vaccine efficacy about 95%. The implications of the epidemic recurrence of measles for attack rates yield an estimate of vaccine efficacy about 95%. The implications of the epidemic recurrence of measles for isolated communities due to suboptimal vaccine coverage are discussed.
1988年，瓦哈卡州圣地亚哥·亚泰佩克发生了一起涉及230例病例的麻疹疫情，罹患率为14%，病死率为3.9%。该社区相对较为孤立。在1至15岁儿童中，疫情暴发前麻疹疫苗接种覆盖率为38.7%。我们比较了接种疫苗者和未接种疫苗者的罹患率，并针对年龄和疫苗信息来源对数据进行了调整。基于这一比较得出的疫苗效力为72%。我们将家庭层面的病例分为原发和继发。继发罹患率为15.5%。基于继发罹患率的比较得出的疫苗效力估计约为95%。麻疹疫情复发对罹患率的影响得出的疫苗效力估计约为95%。本文讨论了疫苗接种覆盖率欠佳导致麻疹在孤立社区再次流行的影响。
