Department of Neurology, Knappschaftskrankenhaus, Ruhr-University of Bochum, In der Schornau 23-25, 44892, Bochum, Germany.
J Neural Transm (Vienna). 2012 Apr;119(4):457-62. doi: 10.1007/s00702-011-0737-z. Epub 2011 Nov 8.
Dysarthria is a prominent feature of progressive supranuclear palsy (PSP) and consists--amongst other features--of impaired speech fluency. Since in Parkinson's disease (PD) steadiness of syllable repetition in the course of the performance has been shown to be impaired, the aim of the present study was to investigate if measurement of syllable repetition shows similar or even more pronounced abnormalities in PSP. Thirty six patients with the clinical diagnosis of PSP (16 PSP-Richardson syndrome/PSP-RS and 20 PSP-parkinsonism/PSP-P), 60 patients with PD and 32 healthy speakers were tested. Participants had to repeat a single syllable in a self chosen isochronous pace. Percental coefficient of variance (COV) of interval length was measured for description of pace stability throughout the performance. All patients were tested according to Unified Parkinson's Disease Rating Scale (UPDRS III). Patients with PSP were additionally scored according to PSP rating scale (PSPRS). In the PSP group, COV was significantly worse not only when compared with healthy speakers but also when compared with PD patients of similar disease duration and similar global motor impairment. COV showed only a trend to higher values in the subgroup with PSP-RS as compared to PSP-P. In the PSP-P, but not in the PSP-RS subgroup, there was a positive correlation between COV and PSPRS/UPDRS III. PSP patients feature more pronounced difficulties in the steady syllable repetition than patients with PD and healthy controls as a hint for a more profound dysfunction of basal motor speech performance in PSP than in PD.
构音障碍是进行性核上性麻痹（PSP）的一个显著特征，包括言语流畅性受损等特征。由于在帕金森病（PD）中，音节重复的稳定性在疾病过程中已经被证明受到损害，因此本研究的目的是调查音节重复测量是否在 PSP 中显示出类似甚至更明显的异常。36 名临床诊断为 PSP 的患者（16 名 PSP-Richardson 综合征/PSP-RS 和 20 名 PSP-帕金森病/PSP-P）、60 名 PD 患者和 32 名健康说话者接受了测试。参与者必须以自我选择的等时节奏重复一个单音节。间隔长度的百分比方差（COV）用于描述整个表现过程中的节奏稳定性。所有患者均根据统一帕金森病评定量表（UPDRS III）进行测试。PSP 患者还根据 PSP 评定量表（PSPRS）进行评分。在 PSP 组中，COV 不仅明显差于健康对照组，而且与疾病持续时间和相似整体运动障碍相似的 PD 患者相比也较差。与 PSP-P 相比，PSP-RS 亚组的 COV 值更高，但仅呈趋势。在 PSP-P 亚组中，但在 PSP-RS 亚组中，COV 与 PSPRS/UPDRS III 之间存在正相关。PSP 患者在稳定音节重复方面的困难比 PD 患者和健康对照组更明显，这表明 PSP 中基底运动言语表现的功能障碍比 PD 更严重。
