Ogunshe Adenike A O, Omotoso Oluwatoyin A, Akindele Titilayo M
East Afr J Public Health. 2011 Jun;8(2):112-8.
The study aims at evaluating the potentials of soaps and germicides/disinfectants as adjunct topical anti-vulvovaginal candidasis agents.
In vitro inhibitory activities of the test agents, prepared according to the manufacturer's specification for toilet and midwifery purposes were determined using modified agar well-diffusion method.
Varied susceptibility patterns were exhibited by Candida albicans (26.5%), C. glabrata (18.4%), C. pseudotropicalis (14.3%) and C. tropicalis (40.8%) implicated in vulvovaginal candidasis, indicating Crusader oil (100%), Meriko (95%), Tetmosol (84.7%) and Aloe (68.4%) as the most inhibitory soaps against the Candida strains. The in vitro inhibitory activities of the germicides and disinfectants ranged between (Dettol; 34.6% and Purit; 84.6%) for C. albicans; (Roberts; 33.3% and Purit; 83.3%) for C. glabrata; (Roberts; 21.4% and Purit; 92.9%) for C. pseudotropicalis; (Dettol; 35.0% and Purit; 87.5%) for C. tropicalis respectively. All the Candida strains were totally inhibited by the germicides and disinfectants at the second lower dilutions, except in Morigad towards C. albicans (69.2%]) C. glabrata (72.2%), C. pseudotropicalis (92.9%) and C. tropicalis (82.5%) but none of the vaginal Lactobacillus strains was inhibited by the soaps, germicides or disinfectant. About 90% of a control group indicated relief after pubic cleansing with soaps, germicides and disinfectants.
Results indicatied the safety of soaps, germicides and disinfectants as potential adjunct topical cleansing-agents in cases of vaginal itching and candidasis, a common mucosal infection caused by opportunistic yeasts of the Candida genus.
本研究旨在评估肥皂和杀菌剂/消毒剂作为辅助局部抗外阴阴道念珠菌病药物的潜力。
采用改良琼脂孔扩散法测定按照制造商用于厕所和助产目的的规格制备的受试药物的体外抑制活性。
与外阴阴道念珠菌病相关的白色念珠菌（26.5%）、光滑念珠菌（18.4%）、近平滑念珠菌（14.3%）和热带念珠菌（40.8%）呈现出不同的药敏模式，表明十字军油（100%）、美利可（95%）、泰特莫索尔（84.7%）和芦荟（68.4%）是对念珠菌菌株最具抑制作用的肥皂。对于白色念珠菌，杀菌剂和消毒剂的体外抑制活性范围在（滴露；34.6%和普瑞特；84.6%）之间；对于光滑念珠菌，在（罗伯茨；33.3%和普瑞特；83.3%）之间；对于近平滑念珠菌，在（罗伯茨；21.4%和普瑞特；92.9%）之间；对于热带念珠菌，在（滴露；35.0%和普瑞特；87.5%）之间。除了在莫里加德对白色念珠菌（69.2%）、光滑念珠菌（72.2%）、近平滑念珠菌（92.9%）和热带念珠菌（82.5%）的情况外，所有念珠菌菌株在第二低稀释度时都被杀菌剂和消毒剂完全抑制，但没有一种阴道乳酸杆菌菌株被肥皂、杀菌剂或消毒剂抑制。对照组中约90%的人在用肥皂、杀菌剂和消毒剂进行阴部清洁后表示症状缓解。
结果表明，肥皂、杀菌剂和消毒剂作为阴道瘙痒和念珠菌病（一种由念珠菌属机会性酵母菌引起的常见黏膜感染）潜在的辅助局部清洁药物是安全的。
