Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Food Chem Toxicol. 2012 Feb;50(2):310-4. doi: 10.1016/j.fct.2011.10.063. Epub 2011 Oct 31.
The present study investigates hepatoprotective effects of polyphenol rich Murraya koenigii L. (MK) hydro-ethanolic leaf extract in CCl(4) treated hepatotoxic rats. Plasma markers of hepatic damage, lipid peroxidation levels, enzymatic, and non-enzymatic antioxidants in liver and histopathological changes were investigated in control and treated rats. MK pretreated rats with different doses (200, 400 and 600mg/kg body weight) showed significant decrement in activity levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and bilirubin. Also, MK treated rats recorded a dose dependent increment in hepatic super oxide dismutase, catalase, reduced glutathione and ascorbic acid and, a decrement in lipid peroxidation. Microscopic evaluations of liver revealed CCl(4)-induced lesions and related toxic manifestations that were minimal in liver of rats pretreated with MK extract. These results demonstrate that hydro-ethanolic leaf extract of MK possesses hepatoprotective potentials.
本研究调查了富含多酚的芸香科（MK）水醇叶提取物对 CCl（4）处理的肝毒性大鼠的保肝作用。在对照和治疗大鼠中研究了血浆肝损伤标志物、脂质过氧化水平、肝酶和非酶抗氧化剂以及组织病理学变化。用不同剂量（200、400 和 600mg/kg 体重）的 MK 预处理大鼠，丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、总蛋白和胆红素的活性水平显著降低。此外，MK 治疗组大鼠的肝超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽和抗坏血酸的活性呈剂量依赖性增加，而脂质过氧化水平降低。肝的显微镜评估显示，CCl（4）诱导的损伤和相关毒性表现，在 MK 提取物预处理的大鼠肝中最小。这些结果表明，MK 的水醇叶提取物具有保肝潜力。
