Balakrishnan Rengasamy, Vijayraja Dhanraj, Jo Song-Hee, Ganesan Palanivel, Su-Kim In, Choi Dong-Kug
Department of Applied Life Sciences and Integrated Bioscience, Graduate School, Konkuk University, Chungju 27478, Korea.
Department of Biochemistry, Rev. Jacob Memorial Christian College, Ambilikkai-624612, Tamilnadu, India.
Antioxidants (Basel). 2020 Jan 24;9(2):101. doi: 10.3390/antiox9020101.
The discovery of several revitalizing molecules that can stop or reduce the pathology of a wide range of diseases will be considered a major breakthrough of the present time. Available synthetic compounds may provoke side effects and health issues, which heightens the need for molecules from plants and other natural resources under discovery as potential methods of replacing synthetic compounds. In traditional medicinal therapies, several plant extracts and phytochemicals have been reported to impart remedial effects as better alternatives. ( ) belongs to the Rutaceae family, which is commonly used as a medicinally important herb of Indian origin in the Ayurvedic system of medicine. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and pharmacological effects. These include antioxidant, antidiabetic, anti-inflammatory, antitumor, and neuroprotective activities. The present review provides insight into the major components of and their pharmacological activities against different pathological conditions. The review also emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of and its derivatives as potent therapeutic agents.
发现几种能够阻止或减轻多种疾病病理状况的焕活分子将被视为当今的一项重大突破。现有的合成化合物可能会引发副作用和健康问题，这就更需要从植物和其他正在探索的自然资源中寻找分子，作为替代合成化合物的潜在方法。在传统医学疗法中，据报道，几种植物提取物和植物化学物质具有更好的替代治疗效果。（ ）属于芸香科，在阿育吠陀医学体系中，它是一种常用的具有重要药用价值的印度本土草药。先前的报道表明，这种植物的叶子、根和树皮富含咔唑生物碱，这些生物碱具有强大的生物活性和药理作用。这些作用包括抗氧化、抗糖尿病、抗炎、抗肿瘤和神经保护活性。本综述深入探讨了（ ）的主要成分及其针对不同病理状况的药理活性。该综述还强调，需要在各种细胞和动物模型中对这种活性的分子基础进行更多研究，以验证（ ）及其衍生物作为有效治疗剂的功效。
