Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease.
作者信息
Gudjonsson O, Sanz E, Alván G, Aquilonius S M, Reviriego J
出版信息
Br J Clin Pharmacol. 1990 Aug;30(2):301-2. doi: 10.1111/j.1365-2125.1990.tb03780.x.
Abstract
摘要
相似文献
1
Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease.在一组帕金森病患者中，异喹胍和S-美芬妥因的羟化酶表型不佳的情况并未过度出现。
Br J Clin Pharmacol. 1990 Aug;30(2):301-2. doi: 10.1111/j.1365-2125.1990.tb03780.x.
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Lack of relationship between glibenclamide metabolism and debrisoquine or mephenytoin hydroxylation phenotypes.格列本脲代谢与异喹胍或美芬妥因羟化表型之间缺乏相关性。
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Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians.爱沙尼亚人对异喹胍和苯妥英羟化作用的多态性
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Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes.美芬妥英和异喹胍羟基化表型随时间的再现性。
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Polymorphic debrisoquine and mephenytoin hydroxylation in patients with pulmonary hypertension of vascular origin after aminorex fumarate.富马酸氨基苯唑后血管性肺动脉高压患者中多态性异喹胍和美芬妥因的羟基化作用
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Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.地西泮治疗不影响异喹胍或美芬妥英羟化表型试验。
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Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man.美芬妥英的药物遗传学：人类一种新的药物羟基化多态性
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d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo.右旋丙氧芬是去甲异喹胍的强效抑制剂，但在体内对S-美芬妥因4-羟化无抑制作用。
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Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.遗传因素在地西泮代谢调节中的重要性：与S-美芬妥因而非异喹胍羟化表型的关系。
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Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism.高加索人中美芬妥英羟化缺乏症：一种新的氧化药物代谢多态性的频率
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本文引用的文献
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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.人类因哌替啶类似物合成产物导致的慢性帕金森症。
Science. 1983 Feb 25;219(4587):979-80. doi: 10.1126/science.6823561.
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Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography.
J Chromatogr. 1984 Apr 13;307(1):121-7. doi: 10.1016/s0378-4347(00)84078-5.
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The metabolism of insecticides: the role of monooxygenase enzymes.杀虫剂的代谢：单加氧酶的作用。
Annu Rev Pharmacol Toxicol. 1984;24:19-42. doi: 10.1146/annurev.pa.24.040184.000315.
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Predicting Parkinson's disease.预测帕金森病。
Nature. 1985;317(6034):198-9. doi: 10.1038/317198a0.
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Comparative behavioral, biochemical and pigmentary effects of MPTP, MPP+ and paraquat in Rana pipiens.MPTP、MPP⁺和百草枯对豹蛙的行为、生化及色素沉着的比较影响
Life Sci. 1985 Oct 21;37(16):1529-38. doi: 10.1016/0024-3205(85)90185-7.
6
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.
Biochem Biophys Res Commun. 1987 Nov 13;148(3):1144-50. doi: 10.1016/s0006-291x(87)80252-8.
7
Polymorphic debrisoquin hydroxylation in 757 Swedish subjects.
Clin Pharmacol Ther. 1988 Oct;44(4):431-5. doi: 10.1038/clpt.1988.176.
8
Debrisoquine metabolism in parkinsonian patients treated with antihistamine drugs.帕金森病患者使用抗组胺药治疗时的异喹胍代谢
Lancet. 1987 Aug 15;2(8555):386. doi: 10.1016/s0140-6736(87)92396-8.
9
Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine.帕金森病的生态遗传学：异喹胍的4-羟化作用。
Lancet. 1985 Nov 30;2(8466):1213-6. doi: 10.1016/s0140-6736(85)90743-3.
10
S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin.与地布喹合用后确定的瑞典人群中S-美芬妥因的羟化表型。
Clin Pharmacol Ther. 1989 May;45(5):495-9. doi: 10.1038/clpt.1989.63.
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