Department of Urology, Eberhard-Karls University, Tubingen, Germany.
Cancer Lett. 2012 Mar;316(1):6-10. doi: 10.1016/j.canlet.2011.10.025. Epub 2011 Nov 6.
Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated. TK1 might be helpful for screening and monitoring of human malignancies. TK1 may also serve as a prognostic factor for progression. Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given.
胸苷激酶（TK）在 DNA 的合成中具有关键作用。已经鉴定出两种同工酶：TK1 是细胞周期依赖性的，存在于细胞质中，而位于线粒体中的 TK2 则是细胞周期非依赖性的。TK1 的诊断和预后作用最近得到了研究。TK1 可能有助于筛选和监测人类恶性肿瘤。TK1 也可能作为进展的预后因素。本文总结了 TK1 在癌症监测中的地位，并指出其作为增殖标志物的用途。还全面概述了 TK-1 与各种实体的关联。
