Mammalian Developmental Epigenetics Group, Genetics and Developmental Biology Unit, Institut Curie, CNRS UMR3215, INSERM U934, 75248 Paris, France.
Development. 2011 Dec;138(23):5049-55. doi: 10.1242/dev.068320.
The third X-inactivation meeting 'Fifty years of X-inactivation research', which celebrated the fiftieth anniversary of Mary Lyon's formulation of the X-inactivation hypothesis, was an EMBO workshop held in Oxford, UK, in July 2011. This conference brought together the usual suspects from the field, as well as younger researchers, to discuss recent advances in X-inactivation research. Here, we review the results presented at the meeting and highlight some of the exciting progress that has been made. We also discuss the future challenges for the field, which aim to further our understanding of the developmental regulation of X inactivation, the randomness (or skewing) of X inactivation, and the diverse strategies used by mammalian species to mediate X inactivation.
第三届 X 染色体失活会议“X 染色体失活研究五十年”于 2011 年 7 月在英国牛津举行，庆祝了 Mary Lyon 提出 X 染色体失活假说五十周年。此次会议是由欧洲分子生物学组织举办的研讨会，聚集了该领域的资深研究人员和年轻研究人员，共同讨论 X 染色体失活研究的最新进展。在这里，我们回顾了会议上提出的结果，并强调了已经取得的一些令人兴奋的进展。我们还讨论了该领域未来的挑战，旨在进一步了解 X 染色体失活的发育调控、X 染色体失活的随机性（或偏斜）以及哺乳动物物种用于介导 X 染色体失活的不同策略。
