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细胞毒性坏死因子（CNFs）——不断发展的毒素家族。

Cytotoxic Necrotizing Factors (CNFs)-A Growing Toxin Family.

机构信息

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany.

出版信息

Toxins (Basel). 2010 Jan;2(1):116-27. doi: 10.3390/toxins2010116. Epub 2011 Apr 8.

DOI:10.3390/toxins2010116
PMID:22069550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3206620/
Abstract

The Escherichia coli Cytotoxic Necrotizing Factors, CNF1, CNF2, CNF3 and CNFY from Yersinia pseudotuberculosis belong to a family of deamidating toxins. CNFs deamidate glutamine 63/61 in the switch II region of Rho GTPases that is essential for GTP hydrolysing activity. Deamidation leads to constitutive activation of Rho GTPases. However, cellular mechanisms like proteasomal degradation of the activated Rho proteins restrict the action of the GTPases. This review describes the differences between the toxin family members concerning expression, cellular entry and substrate specificity.

摘要

产志贺毒素大肠杆菌细胞毒素（Escherichia coli Cytotoxic Necrotizing Factors，CNF）1、2、3 和 Yersinia pseudotuberculosis 的 CNFY 属于去酰胺毒素家族。CNF 去酰胺化 Rho GTPases 开关 II 区域的谷氨酰胺 63/61，这对 GTP 水解活性至关重要。去酰胺化导致 Rho GTPases 的组成性激活。然而，细胞机制如激活的 Rho 蛋白的蛋白酶体降解限制了 GTP 酶的作用。本综述描述了毒素家族成员在表达、细胞进入和底物特异性方面的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/50f195979314/toxins-02-00116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/1f6a3c177e99/toxins-02-00116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/a56e43ac4c05/toxins-02-00116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/50f195979314/toxins-02-00116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/1f6a3c177e99/toxins-02-00116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/a56e43ac4c05/toxins-02-00116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f096/3206620/50f195979314/toxins-02-00116-g003.jpg

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