Department of Biology, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy.
Toxins (Basel). 2010 Apr;2(4):417-27. doi: 10.3390/toxins2040417. Epub 2010 Mar 25.
Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxins has been achieved through different approaches: plant extracts have been utilized in etnomedicine. Direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases. This mini-review summarizes new achievements in venom key component inhibition. A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy.
蛇毒是复杂的毒素混合物。蝰蛇科和响尾蛇科的毒液具有血液毒性，是造成全球大多数蛇伤的罪魁祸首。抗蛇毒血清的使用旨在中和人体内的毒素，但也存在潜在风险。已经通过不同的方法实现了对蛇毒毒素的中和：植物提取物在民族医学中得到了应用。低电压的直流电显示出对毒液磷脂酶 A2 和金属蛋白酶的中和特性。本综述总结了蛇毒关键成分抑制方面的新进展。深入了解抑制蛇毒毒素的替代方法可能为血清治疗提供补充治疗。
