United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, National Center for Natural Products Research, Post Office Box 8048, University of Mississippi, 38677, USA.
Toxins (Basel). 2010 Jul;2(7):1676-89. doi: 10.3390/toxins2071676. Epub 2010 Jun 28.
The bacteria Edwardsiella ictaluri and Flavobacterium columnare cause enteric septicemia and columnaris disease, respectively, in channel catfish (Ictalurus punctatus). Natural therapeutants may provide an alternative to current management approaches used by producers. In this study, a rapid bioassay identified plant compounds as potential therapeutants. Chelerythrine chloride and ellagic acid were the most toxic toward E. ictaluri, with 24-h IC50 of 7.3 mg/L and 15.1 mg/L, respectively, and MIC of 2.1 mg/L and 6.5 mg/L, respectively. Chelerythrine chloride, ellagic acid, β-glycyrrhetinic acid, sorgoleone, and wogonin were the most toxic towards two genomovars of F. columnare, and wogonin had the strongest antibacterial activity (MIC = 0.3 mg/L).
爱德华氏菌和柱状屈挠杆菌分别引起斑点叉尾鮰的肠败血症和柱状病。天然治疗剂可能为生产者目前使用的管理方法提供替代方案。在这项研究中，快速生物测定法确定了植物化合物作为潜在的治疗剂。白屈菜红碱和鞣花酸对爱德华氏菌的毒性最大，其 24 小时 IC50 分别为 7.3mg/L 和 15.1mg/L，MIC 分别为 2.1mg/L 和 6.5mg/L。白屈菜红碱、鞣花酸、β-甘草次酸、山梗菜酮和汉黄芩素对两种柱状屈挠杆菌基因组变种的毒性最大，而汉黄芩素具有最强的抗菌活性（MIC=0.3mg/L）。
