Nik Mohamad Nek Rahimi Naqiuddin, Natrah Ikhsan, Loh Jiun-Yan, Ervin Ranzil Francis Kumar, Gina Madi, Lim Swee-Hua Erin, Lai Kok-Song, Chong Chou-Min
Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Department of Aquaculture, Faculty of Agriculture, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Antibiotics (Basel). 2022 Mar 31;11(4):469. doi: 10.3390/antibiotics11040469.
Despite culturing the fastest-growing animal in animal husbandry, fish farmers are often adversely economically affected by pathogenic disease outbreaks across the world. Although there are available solutions such as the application of antibiotics to mitigate this phenomenon, the excessive and injudicious use of antibiotics has brought with it major concerns to the community at large, mainly due to the rapid development of resistant bacteria. At present, the use of natural compounds such as phytocompounds that can be an alternative to antibiotics is being explored to address the issue of antimicrobial resistance (AMR). These phytocompounds are bioactive agents that can be found in many species of plants and hold much potential. In this review, we will discuss phytocompounds extracted from plants that have been evidenced to contain antimicrobial, antifungal, antiviral and antiparasitic activities. Further, it has also been found that compounds such as terpenes, phenolics, saponins and alkaloids can be beneficial to the aquaculture industry when applied. This review will focus mainly on compounds that have been identified between 2000 and 2021. It is hoped this review will shed light on promising phytocompounds that can potentially and effectively mitigate AMR.
尽管鱼类是畜牧业中生长速度最快的养殖动物,但世界各地的养鱼户经常受到病原性疾病爆发的不利经济影响。虽然有抗生素应用等可用解决方案来缓解这一现象,但抗生素的过度和不当使用给整个社会带来了重大担忧,主要是因为耐药细菌的迅速发展。目前,正在探索使用天然化合物,如可替代抗生素的植物化合物,来解决抗菌药物耐药性(AMR)问题。这些植物化合物是生物活性剂,可在许多植物物种中找到,具有很大潜力。在本综述中,我们将讨论从植物中提取的已被证明具有抗菌、抗真菌、抗病毒和抗寄生虫活性的植物化合物。此外,还发现萜类、酚类、皂苷和生物碱等化合物在应用时对水产养殖业有益。本综述将主要关注2000年至2021年间已确定的化合物。希望本综述能揭示有潜力有效缓解AMR的有前景的植物化合物。