FELS Institute, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA.
Toxins (Basel). 2010 Jul;2(7):1704-17. doi: 10.3390/toxins2071704. Epub 2010 Jun 30.
Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.
金黄色葡萄球菌肠毒素具有免疫调节特性。在这项研究中，我们表明金黄色葡萄球菌肠毒素 A (SEA) 可在不依赖 MHC Ⅱ类表达细胞的情况下诱导小鼠 T 细胞克隆发生强烈的增殖反应。SEA 刺激还可诱导一种低反应性（无能）状态。我们对 SEA 诱导无能时 T 细胞受体（TCR）的组成成分进行了特征描述。最有趣的是，SEA 无能条件下 TCR ζ 链的磷酸化缺失，这表明 ζ 链功能的解偶联。我们在此描述了一种在不存在混杂共刺激信号的情况下研究无能的模型系统。
