Department of Immunology-MC3710, University of Connecticut Heath Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
Toxins (Basel). 2010 Jul;2(7):1898-912. doi: 10.3390/toxins2071898. Epub 2010 Jul 21.
In response to environmental cues the human pathogen Staphylococcus aureus synthesizes and releases proteinaceous enterotoxins. These enterotoxins are natural etiologic entities of severe food poisoning, toxic shock syndrome, and acute diseases. Staphylococcal enterotoxins are currently listed as Category B Bioterrorism Agents by the Center for Disease Control and Prevention. They are associated with respiratory illnesses, and may contribute to exacerbation of pulmonary disease. This likely stems from the ability of Staphylococcal enterotoxins to elicit powerful episodes of T cell stimulation resulting in release of pro-inflammatory cytokines. Here, we discuss the role of the immune system and potential mechanisms of disease initiation and progression.
为了应对环境线索，人类病原体金黄色葡萄球菌会合成并释放蛋白质肠毒素。这些肠毒素是严重食物中毒、中毒性休克综合征和急性疾病的天然病因。金黄色葡萄球菌肠毒素目前被疾病控制和预防中心列为 B 类生物恐怖主义制剂。它们与呼吸道疾病有关，并可能导致肺部疾病恶化。这可能源于金黄色葡萄球菌肠毒素引起强烈的 T 细胞刺激反应，导致促炎细胞因子释放的能力。在这里，我们讨论了免疫系统的作用以及疾病发生和进展的潜在机制。
