Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Göteborg, Sweden.
Infect Immun. 2010 Jan;78(1):381-6. doi: 10.1128/IAI.00724-09. Epub 2009 Oct 12.
T-helper 17 (Th17) cells are characterized by their production of interleukin-17 (IL-17) and have a role in the protection against infections and in certain inflammatory diseases. Humans who lack Th17 cells are more susceptible to Staphylococcus aureus infections compared to individuals having Th17 cells. S. aureus is part of the commensal skin microflora and also colonize the infant gut. To investigate whether UV-killed S. aureus would be more capable of inducing IL-17 than other commensal bacteria, we stimulated mononuclear cells from adults, infants, and newborns with various gram-positive and gram-negative commensal bacteria. IL-17 was produced from adult memory Th17 cells after stimulation with superantigen-producing S. aureus but not nonsuperantigenic S. aureus or other common commensal gut bacteria. Cells from newborns were poor IL-17 producers after stimulation with S. aureus, whereas in some cases IL-17 was secreted from cells isolated from infants at the age of 4 and 18 months. These results suggest that superantigenic S. aureus are particularly efficient in stimulating IL-17 production and that the cytokine is produced from memory T cells.
辅助性 T 细胞 17（Th17）细胞的特征是其产生白细胞介素 17（IL-17），并在抗感染和某些炎症性疾病中发挥作用。与具有 Th17 细胞的个体相比，缺乏 Th17 细胞的人更容易受到金黄色葡萄球菌感染。金黄色葡萄球菌是共生皮肤微生物群的一部分，也定植于婴儿肠道。为了研究经紫外线杀灭的金黄色葡萄球菌是否比其他共生细菌更能诱导白细胞介素 17 的产生，我们用各种革兰氏阳性和革兰氏阴性共生菌刺激成人、婴儿和新生儿的单核细胞。刺激产生超抗原的金黄色葡萄球菌后，来自成人记忆 Th17 细胞的白细胞介素 17 被产生，但非超抗原性金黄色葡萄球菌或其他常见共生肠道细菌则没有。新生儿的金黄色葡萄球菌刺激后，白细胞介素 17 的产生能力较差，而在某些情况下，从 4 个月和 18 个月大婴儿分离的细胞中分泌出白细胞介素 17。这些结果表明，超抗原性金黄色葡萄球菌在刺激白细胞介素 17 产生方面特别有效，并且该细胞因子由记忆 T 细胞产生。
