Kern David G, Kern Eli, Crausman Robert S, Clapp Richard W
Department of Medicine, Maine VA Medical Center, Augusta, ME, USA.
Int J Occup Environ Health. 2011 Oct-Dec;17(4):345-51. doi: 10.1179/107735211799041814.
During an investigation of a novel interstitial lung disease in a cohort of nylon flock workers, a former worker was found to have developed bilateral synchronous pulmonary adenocarcinomas three decades after he quit smoking, suggesting that exposures in this industry might pose excessive risk of lung cancer. We conducted a retrospective cohort study of lung cancer incidence in the original study cohort (n=162) from August 15, 1998, to August 14, 2008. The Rhode Island Cancer Registry identified cohort members with lung cancer and provided age-gender-era-specific rates of lung cancer in Rhode Island. Five cases of lung cancer occurred among cohort members versus 1.61 cases expected for a standardized incidence ratio of 3.1 (95% CI, 1.01-7.23). The observed threefold increase in lung cancer incidence could not be readily ascribed to chance, study bias, or uncontrolled confounding. Workers in this industry should be notified of their potentially increased risk of lung cancer.
在对一组尼龙绒毛工人中的一种新型间质性肺病进行调查期间，一名曾在此行业工作的工人在戒烟30年后被发现患了双侧同步肺腺癌，这表明该行业的接触可能会带来过高的肺癌风险。我们对1998年8月15日至2008年8月14日期间原研究队列（n = 162）中的肺癌发病率进行了一项回顾性队列研究。罗德岛癌症登记处确定了队列中患肺癌的成员，并提供了罗德岛特定年龄、性别、时期的肺癌发病率。队列成员中发生了5例肺癌，而预期为1.61例，标准化发病比为3.1（95%可信区间，1.01 - 7.23）。观察到的肺癌发病率增加三倍不太可能轻易归因于偶然、研究偏倚或未控制的混杂因素。应告知该行业的工人其患肺癌的潜在风险增加。
