Chasovnikova L V, Formaziuk V E, Sergienko V I, Vlasimirov Iu A
Biofizika. 1990 May-Jun;35(3):464-8.
For modeling anticataract drugs diffusion into the lens surface tension of drugs, their solubility in nonpolar solvent and drug adsorption at air-water and water-lipid monolayer surface were measured. It has been shown that diffusion of many drugs into the lens is limited by their low solubility in a monolayer phase of the membrane. Catachrom concentration in the lens should be the highest, because it can concentrate at interfaces.
为了模拟抗白内障药物向晶状体的扩散，测量了药物的表面张力、它们在非极性溶剂中的溶解度以及药物在空气-水和水-脂质单分子层表面的吸附情况。结果表明，许多药物向晶状体的扩散受到其在膜单分子层相中低溶解度的限制。Catachrom在晶状体中的浓度应该是最高的，因为它可以在界面处浓缩。
