Allen G D
Department of Drug Metabolism and Pharmacokinetics, Beecham Pharmaceuticals Research Division, Medicinal Research Centre, Harlow, Essex, England.
Biopharm Drug Dispos. 1990 Aug-Sep;11(6):477-98. doi: 10.1002/bdd.2510110603.
This paper presents a computer program, MODFIT, written in FORTRAN, primarily for use on the Digital Equipment Company VAX series computers for the mathematical analysis of concentration-time data. Drug data generated from biological fluids and tissues may be fitted by a variety of different models. For many models, parameter starting estimates are program generated prior to automatic nonlinear regression analysis using a modified Davidon-Fletcher-Powell algorithm. The output of results is extensive and plotting facilities are available. Explicit and differential equation models may be fitted to single dose data and simulations using all models (single or repeat dose) may be employed to generate drug concentration-time data with plotting output. The package has been tested on numerous data with no problems regarding local function minima. Some comparisons with existing programs have been made and MODFIT compares well with respect to robustness, efficiency, and ease of use.
本文介绍了一个用FORTRAN编写的计算机程序MODFIT，主要用于数字设备公司的VAX系列计算机，对浓度-时间数据进行数学分析。从生物流体和组织中产生的药物数据可以用多种不同模型进行拟合。对于许多模型，在使用改进的大卫登-弗莱彻-鲍威尔算法进行自动非线性回归分析之前，程序会生成参数初始估计值。结果输出丰富，并且具备绘图功能。显式和微分方程模型可以拟合单剂量数据，使用所有模型（单剂量或重复剂量）进行模拟可用于生成带有绘图输出的药物浓度-时间数据。该软件包已在大量数据上进行了测试，不存在局部函数最小值方面的问题。已与现有程序进行了一些比较，MODFIT在稳健性、效率和易用性方面表现良好。
