Fukushima Kei, Takeuchi Hiromi, Morizane Rie, Kitano Hiroya, Sakoda Takema, Enomoto Tadao
Department of Otolaryngology, Head and Neck Surgery, Faculty Medicine, Tottori University, Yonago.
Nihon Jibiinkoka Gakkai Kaiho. 2011 Sep;114(9):774-9. doi: 10.3950/jibiinkoka.114.774.
Given that the nasal discharge of subjects with allergic rhinitis contains IgE, we studied nonspecific IgE potential in nasal discharge as a diagnostic marker for allergic rhinitis. We divided 38 adults into 2 groups, one with 22 with Japanese cedar pollinosis and one with 16 with watery rhinorrhea negative to MAST33. The pollinosis group was exposed to Japanese cedar pollen in an environmental exposure unit, and eosinophils in nasal discharge, serum total IgE, pollen-specific IgE, and local IgE in nasal discharge were examined for the 2 groups to determine IgE levels in nasal discharge using the Allerwatch rapid test. In the pollinosis group, nasal discharge IgE correlated significantly with the number of eosinophils. The nasal discharge IgE had higher specificity than the eosinophil examination, whereas nasal discharge eosinophils had higher sensitivity than the IgE examination. We thus found that measuring IgE and eosinophils in nasal discharge is useful for clinically diagnosing allergic rhinitis.
鉴于过敏性鼻炎患者的鼻分泌物中含有免疫球蛋白E（IgE），我们研究了鼻分泌物中的非特异性IgE潜力，将其作为过敏性鼻炎的诊断标志物。我们将38名成年人分为两组，一组22人患有日本雪松花粉症，另一组16人鼻水样分泌物对MAST33检测呈阴性。花粉症组在环境暴露单元中接触日本雪松花粉，对两组的鼻分泌物嗜酸性粒细胞、血清总IgE、花粉特异性IgE和鼻分泌物局部IgE进行检测，使用Allerwatch快速检测法测定鼻分泌物中的IgE水平。在花粉症组中，鼻分泌物IgE与嗜酸性粒细胞数量显著相关。鼻分泌物IgE比嗜酸性粒细胞检查具有更高的特异性，而鼻分泌物嗜酸性粒细胞比IgE检查具有更高的敏感性。因此，我们发现检测鼻分泌物中的IgE和嗜酸性粒细胞对过敏性鼻炎的临床诊断很有用。
