High performance liquid chromatography determination of doxorubicin and daunorubicin in plasma using UV detection and column switching.
作者信息
Mikan A, Martinez Lanao J, Gonzalez Lopez F, Dominguez-Gil Hurle A
机构信息
JZD Agrokombinat, Slusovice, Czechoslovakia.
出版信息
Biomed Chromatogr. 1990 Jul;4(4):154-6. doi: 10.1002/bmc.1130040408.
PMID:2207376
Abstract
A method for the determination of doxorubicin and daunorubicin in plasma is described. The plasma is injected directly into a loop column and then washed with water. After switching the injection valve, the sample is separated on a phenyl column using detection at 254 nm. The detection limit is 10 ng/mL, the coefficient of variation is 7% for 100 ng/mL of doxorubicin and 4% for 200 ng/mL of daunorubicin.
摘要
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