Maastricht University, Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, 6200 MD, Maastricht, The Netherlands.
Nutr Metab (Lond). 2011 Nov 10;8(1):79. doi: 10.1186/1743-7075-8-79.
Triacylglycerols (TAG) have been shown to have potential appetite suppressing effects. This study examined the effects of 3 g and 6 g Korean pine nut triacylglycerols (PinnoThin) on appetite and energy intake.
130 g Isoenergetic yogurt containing either placebo (milk fat) or PinnoThin TAG was consumed as a breakfast, after an overnight fast, in a double blind randomized crossover design. Appetite profile ratings were determined by visual analogue scale at regular intervals for a period of 4 h after the breakfast. In phase I, 6 g PinnoThin TAG and placebo was tested in thirty-three healthy women (mean ± SD, BMI 26.4 ± 3.8 kg/m2; age 28 ± 10 y) to determine the appetite suppressing effect in time. In phase II, an additional dose of 3 g PinnoThin TAG, as well as 6 g PinnoThin TAG and placebo, was tested in thirty-four women (BMI 25.8 ± 2.9 kg/m2; age 25 ± 9 y) to determine energy intake from an ad libitum lunch offered at 210 min after the breakfast, at which maximal differences in appetite profile ratings were present in phase I.
Area under the curve of appetite profile ratings was not significantly different between the conditions. Energy intake was 9.5% lower after 6 g PinnoThin TAG compared with 3 g PinnoThin TAG, but there was no significant difference with the placebo.
A dosage of 6 g PinnoThin TAG is not sufficient to suppress appetite and energy intake.
Clinical Trials NCT01034605.
三酰基甘油（TAG）已被证明具有潜在的抑制食欲的作用。本研究探讨了 3 克和 6 克韩国松子三酰基甘油（PinnoThin）对食欲和能量摄入的影响。
在一项双盲随机交叉设计中，志愿者在禁食一夜后，早餐时食用含有安慰剂（乳脂肪）或 PinnoThin TAG 的 130 克等能量酸奶。在早餐后 4 小时的定期时间间隔内，通过视觉模拟量表评估食欲特征评分。在第 I 阶段，在 33 名健康女性（平均 ± SD，BMI 26.4 ± 3.8 kg/m2；年龄 28 ± 10 岁）中测试 6 克 PinnoThin TAG 和安慰剂，以确定时间上的抑制食欲作用。在第 II 阶段，在 34 名女性（BMI 25.8 ± 2.9 kg/m2；年龄 25 ± 9 岁）中测试 3 克 PinnoThin TAG 的额外剂量以及 6 克 PinnoThin TAG 和安慰剂，以确定在第 I 阶段最大食欲特征评分差异时，从 210 分钟后的自由午餐中摄入的能量。
食欲特征评分的曲线下面积在不同条件之间没有显著差异。与 3 克 PinnoThin TAG 相比，6 克 PinnoThin TAG 的能量摄入低 9.5%，但与安慰剂相比没有显著差异。
6 克 PinnoThin TAG 的剂量不足以抑制食欲和能量摄入。
ClinicalTrials.gov NCT01034605。
