Hughes Georgina M, Boyland Emma J, Williams Nicola J, Mennen Louise, Scott Corey, Kirkham Tim C, Harrold Joanne A, Keizer Hiskias G, Halford Jason Cg
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK.
Lipids Health Dis. 2008 Feb 28;7:6. doi: 10.1186/1476-511X-7-6.
Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). In the current study, the effects of a Korean pine nut oil product, PinnoThin, at doses 2 g, 4 g and 6 g triglyceride (TG) and 2 g free fatty acid (FFA), on food intake and appetite were examined in a cross-over double-blind placebo-controlled randomised counter-balanced design in 42 overweight female volunteers. 2 g FFA PinnoThin, given 30 minutes prior to an ad-libitum buffet test lunch, significantly reduced food intake (gram) by 9% (F(4,164) = 2.637, p = 0.036) compared to olive oil control. No significant effect of PinnoThin on macronutrient intake or ratings of appetite were observed. Given the recent data showing that the TG form of PinnoThin may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime. Collectively, these data suggest that PinnoThin may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings.
某些游离脂肪酸已被证明对食物摄入量和自我报告的食欲变化有显著影响；这些影响与内源性胆囊收缩素（CCK）和胰高血糖素样肽-1（GLP-1）释放增加有关。在本研究中，采用交叉双盲安慰剂对照随机平衡设计，对42名超重女性志愿者进行了研究，观察了2克、4克和6克甘油三酯（TG）以及2克游离脂肪酸（FFA）剂量的韩国松子油产品PinnoThin对食物摄入量和食欲的影响。在随意自助午餐试验前30分钟给予2克FFA的PinnoThin，与橄榄油对照相比，食物摄入量（克）显著减少了9%（F(4,164)=2.637, p = 0.036）。未观察到PinnoThin对常量营养素摄入量或食欲评分有显著影响。鉴于最近的数据表明，PinnoThin的TG形式也可能通过增加CCK释放来降低食欲，本研究中发现的TG形式没有任何效果可能归因于给药方案的时间安排。总体而言，这些数据表明，PinnoThin可能会产生饱腹感，这与其对CCK和GLP-1释放的已知作用以及先前观察到的对自我报告食欲评分的影响一致。
