Chiba S, Akihara M, Kogasaka R, Horino K, Nakao T, Urasawa T, Urasawa S, Fukui S
Tohoku J Exp Med. 1979 Mar;127(3):265-71.
In December 1976, an outbreak of acute infectious diarrhea occurred among infants who resided in an infant home in the city of Sapporo. Rotavirus infection was proved in 42 (90%) of 47 infants by serologic and/or electron microscopic examinations. Out of 42 infected infants 38(90%) were clinically affected; diarrhea with or without vomiting in 27 (64%), vomiting without diarrhea in 6 (14%) and only febrile episode in 5 (12%). The remaining 4(10%) infants showed no symptoms. Clinical manifestations seemed to differ depending on age. Diarrhea without vomiting was more common in the patients younger than 6 months of age, and vomiting or fever was more common in the groups of older age. Possible reasons for such an age dependency were discussed on the basis of complement-fixation tests using human and calf strains of rotavirus.
