Goto K, Kurokawa Y, Sato H
Tohoku J Exp Med. 1979 Mar;127(3):289-99. doi: 10.1620/tjem.127.289.
Two transplantable, one mucus-producing (R-1) and the other tubular but less mucinous (R-2), adenocarcinomas were investigated electron microscopically. The R-1 tumor was composed of a large number of intermediate cells and mucus-producing cells, incompletely differentiated goblet-like cells and absorptive-like cells, and a small number of undifferentiated cells. The electron microscopic features of the mucus-producing cells exhibited distinctive features different from those of the epithelium of normal colon. They had highly electron-dense granules, expanded rER, well-developed mitochondria and Golgi apparatus. The R-1 tumor was found to be a well-differentiated adenocarcinoma in agreement with observations by light microscopy, while the R-2 tumor exhibited more malignant features than R-1.
对两种可移植的腺癌进行了电子显微镜研究，一种是产生黏液的（R-1），另一种是管状但黏液较少的（R-2）。R-1肿瘤由大量中间细胞和产生黏液的细胞、未完全分化的杯状样细胞和吸收样细胞以及少量未分化细胞组成。产生黏液的细胞的电子显微镜特征显示出与正常结肠上皮不同的独特特征。它们有高度电子致密的颗粒、扩张的粗面内质网、发达的线粒体和高尔基体。与光学显微镜观察结果一致，发现R-1肿瘤是一种高分化腺癌，而R-2肿瘤表现出比R-1更具恶性的特征。
