School of Medicine, Tzu Chi University Department of Surgical Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Clin Transplant. 2010 Jul-Aug;24(4):E124-9. doi: 10.1111/j.1399-0012.2010.01215.x.
Our aim was to evaluate the relationship between metabolic syndrome and fasting serum leptin concentration in renal transplant recipients.
Fasting blood samples were obtained from 55 renal transplant recipients. Metabolic syndrome and its components were defined using the diagnostic criteria of the International Diabetes Federation.
Thirteen patients (23.6%) had metabolic syndrome. Fasting leptin concentrations were positively correlated with metabolic syndrome (p=0.003). Univariate linear regression analysis indicated fasting serum leptin values were positively correlated with waist circumference (r=0.284; p=0.036), body mass index (r=0.358; p=0.007), body fat mass (r=0.610; p<0.001), triglycerides (r=0.268; p=0.048), high-sensitivity C-reactive protein (hs-CRP) (r=0.377; p=0.005), triceps skinfold (r=0.335; p=0.012), and mid-arm fat area (r=0.351; p=0.009). Multivariate forward stepwise linear regression analysis of the significant variables revealed that body fat mass (R2 change=0.373; p<0.001) and hs-CRP (R2 change=0.045; p=0.049) were the independent predictors of fasting serum leptin concentration.
Serum leptin concentration correlates positively with metabolic syndrome in renal transplant recipients.
评估代谢综合征与肾移植受者空腹血清瘦素浓度之间的关系。
从 55 例肾移植受者中抽取空腹血样。采用国际糖尿病联合会的诊断标准定义代谢综合征及其各组分。
13 例（23.6%）患者患有代谢综合征。空腹瘦素浓度与代谢综合征呈正相关（p=0.003）。单因素线性回归分析表明，空腹血清瘦素值与腰围（r=0.284；p=0.036）、体重指数（r=0.358；p=0.007）、体脂肪量（r=0.610；p<0.001）、甘油三酯（r=0.268；p=0.048）、高敏 C 反应蛋白（hs-CRP）（r=0.377；p=0.005）、肱三头肌皮褶厚度（r=0.335；p=0.012）和上臂中部脂肪面积（r=0.351；p=0.009）呈正相关。对有意义的变量进行多元逐步线性回归分析显示，体脂肪量（R2 变化=0.373；p<0.001）和 hs-CRP（R2 变化=0.045；p=0.049）是空腹血清瘦素浓度的独立预测因子。
血清瘦素浓度与肾移植受者的代谢综合征呈正相关。
