结膜黏膜相关淋巴组织淋巴瘤中的（5；11）易位
Translocation (5; 11) in a conjunctival MALT lymphoma.
作者信息
Clement Cecilia G, Potluri Venkateswara R, Gonzales John, Qian You-Wen
机构信息
Departments of Pathology, University of Texas Medical Branch, Galveston, USA.
出版信息
Int J Clin Exp Pathol. 2011;4(7):722-6. Epub 2011 Sep 30.
Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunopheno-typic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lym-phomas and ocular MALT lymphomas as well.
淋巴瘤是眼附属器最常见的恶性肿瘤，最常见的组织学类型是黏膜相关淋巴组织结外边缘区B细胞淋巴瘤（EMZL，即MALT淋巴瘤）。在此，我们报告一例28岁男性患者，其左侧结膜肿物已有1年。基于形态学和免疫表型研究，诊断为结膜原发性MALT淋巴瘤。染色体分析显示为男性核型，主要染色体异常为t(5;11)(q33;p11.2)易位，据我们所知，这也是MALT淋巴瘤及眼MALT淋巴瘤中首次报道的易位。
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