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鹦鹉热衣原体在眼附属器黏膜相关淋巴组织淋巴瘤中的作用：在淋巴瘤发生中的可能作用和不同的地理分布。

Chlamydia psittaci in ocular adnexa MALT lymphoma: a possible role in lymphomagenesis and a different geographical distribution.

机构信息

Pathology Unit, National Cancer Institute "Giovanni Pascale", Naples, Italy.

出版信息

Infect Agent Cancer. 2012 Apr 2;7:8. doi: 10.1186/1750-9378-7-8.

DOI:10.1186/1750-9378-7-8
PMID:22472082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3355003/
Abstract

Ocular adnexa MALT-lymphomas represent approximatively 5-15% of all extranodal lymphomas. Almost 75% of OAMLs are localized in orbital fat, while 25% of cases involves conjunctive. MALT-lymphomas often recognize specific environmental factors responsible of lymphoma development and progression. In particular as Helicobacter pylori in gastric MALT lymphomas, other bacterial infections have been recognized related to MALT lymphomas in specific site. Recently Chlamydia psittaci has been identified in Ocular Adnexa MALT lymphomas, with variable frequence dependently from geographic areas. Thus bacterial infection is responsible of clonal selection on induced MALT with subsequent lymphoma development. Moreover Chlamydia psittaci could promote chromosomal aberration either through genetic instability as a consequence of induced proliferation and probably through DNA oxidative damage. The most common translocation described in MALT lymphomas affects NF-kB pathway with a substantial antiapoptotic effect. Several therapeutic approaches are now available, but the use of antibiotic-therapy in specific cases, although with conflicting results, could improve the treatment of ocular adnexa MALT lymphomas. In this review we analyse the most relevant features of Ocular adnexa MALT lymphomas, underlining specific biological characteristics mainly related to the potential role of Chlamydia psittaci in lymphomagenesis.

摘要

眼附属器黏膜相关淋巴组织（MALT）淋巴瘤约占所有结外淋巴瘤的 5-15%。几乎 75%的 OAML 位于眶脂肪内，而 25%的病例累及结膜。MALT 淋巴瘤通常识别出导致淋巴瘤发展和进展的特定环境因素。特别是在胃 MALT 淋巴瘤中与幽门螺杆菌有关，其他细菌感染也与特定部位的 MALT 淋巴瘤有关。最近，鹦鹉热衣原体已在眼附属器 MALT 淋巴瘤中被鉴定出来，其频率因地理区域而异。因此，细菌感染负责诱导 MALT 的克隆选择，随后发展为淋巴瘤。此外，鹦鹉热衣原体可能通过诱导增殖导致的遗传不稳定性以及可能通过 DNA 氧化损伤来促进染色体畸变。在 MALT 淋巴瘤中描述的最常见易位涉及 NF-κB 途径，具有实质性的抗凋亡作用。现在有几种治疗方法可用，但在特定情况下使用抗生素治疗，尽管结果存在争议，但可能会改善眼附属器 MALT 淋巴瘤的治疗效果。在这篇综述中，我们分析了眼附属器黏膜相关淋巴组织（MALT）淋巴瘤的最相关特征，强调了主要与鹦鹉热衣原体在淋巴瘤发生中的潜在作用相关的特定生物学特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bda/3355003/67f32cc65055/1750-9378-7-8-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bda/3355003/9d606a8972a9/1750-9378-7-8-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bda/3355003/9d606a8972a9/1750-9378-7-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bda/3355003/c171d2e47563/1750-9378-7-8-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bda/3355003/c0cf36bfb8b1/1750-9378-7-8-3.jpg
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