Samojlik Isidora, Petković Stojan, Mimica-Dukić Neda, Božin Biljana
Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Novi Sad, Serbia.
Phytother Res. 2012 Jun;26(6):820-5. doi: 10.1002/ptr.3638. Epub 2011 Nov 10.
The appearance of common and self-initiative usage of various herbal preparations in everyday practice and life imposes the question of possible interactions with drugs. This survey examined the influence of acute and chronic peppermint oil (PO--Mentha × piperita L., Lamiaceae; prepared as emulsion for oral use) on pentobarbitone-induced sleeping time, analgesic effect of codeine and impairment of motor coordination caused by midazolam in mice. The chemical profile of essential oil was determined by GC-MS. Applied doses of PO were 0.1 and 0.2 mL/kg. Chronic PO intake (in both doses) led to significant decrease of analgesic effect of codeine, while acute intake of PO did not change this effect. Acute PO pretreatment in higher dose caused significant prolongation of pentobarbitone-induced sleeping time, while it was significantly shortened by chronic PO pretreatment at the same dose. Midazolam effect was enhanced and prolonged significantly by chronic PO intake at higher dose, while acute intake of PO did not change this effect. Gut motility was increased only by acute intake of higher PO dose. Regarding the fact that PO produces changes in tested drug effects, the interaction between drugs and phytopreparations containing PO should be additionally followed/confirmed in humans.
在日常实践和生活中，各种草药制剂普遍且自主地被使用，这引发了其与药物可能存在相互作用的问题。本研究调查了急性和慢性给予薄荷油（PO——唇形科薄荷属植物薄荷×胡椒薄荷L.；制成口服乳剂）对小鼠戊巴比妥诱导睡眠时间、可待因镇痛效果以及咪达唑仑引起的运动协调障碍的影响。通过气相色谱 - 质谱联用仪（GC - MS）测定了精油的化学组成。PO的给药剂量为0.1和0.2 mL/kg。慢性摄入PO（两种剂量）均导致可待因镇痛效果显著降低，而急性摄入PO则未改变此效果。较高剂量的急性PO预处理导致戊巴比妥诱导的睡眠时间显著延长，而相同剂量的慢性PO预处理则使其显著缩短。较高剂量的慢性PO摄入显著增强并延长了咪达唑仑的作用，而急性摄入PO则未改变此效果。仅急性摄入较高剂量的PO会增加肠道蠕动。鉴于PO会对受试药物的效果产生影响，药物与含PO的植物制剂之间的相互作用应在人体中进一步追踪/证实。
