Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Fitoterapia. 2012 Dec;83(8):1466-73. doi: 10.1016/j.fitote.2012.08.012. Epub 2012 Aug 25.
Anise (Pimpinella anisum L.; Apiaceae) and its essential oil have been widely used in folk medicine, pharmacy and food industry. Since there are some data about the impact of anise on functions of central nervous system (CNS), the issue of possible interactions with drugs acting in CNS should be considered. This survey aimed to examine the influence of aniseed essential oil (EO) intake on the effects of drugs that act in CNS. The chemical profile of essential oil determined by GC-MS revealed as the main components: trans-anethole (88.49%), γ-himachalene (3.13%), cis-isoeugenol (1.99%), and linalool (1.79%). The effects of codeine, diazepam, midazolam, pentobarbital, imipramine and fluoxetine were tested in mice after 5days of peroral pretreatment with human equivalent dose of aniseed EO (0.3mg/kg). The intake of EO led to significant increase of analgesic effect of codeine. The motor impairment caused by midazolam was enhanced in the group treated by EO. The application of diazepam decreased the number and percentage of entries in open arm in elevated maze plus test in the group pretreated with EO indicating augmented effect of drug on motor activity. EO pretreatment caused significant shortage of pentobarbital induced sleeping time when compared to control. The decrease in antidepressant effect of imipramine and fluoxetine was diminished by the pretreatment with aniseed EO. Based on the results of this study we conclude that concomitant intake of aniseed EO preparations and drugs that act on CNS should be avoided due to potential herb-drug interactions, which also need further clinical confirmation.
八角（Pimpinella anisum L.；伞形科）及其精油在民间医学、药学和食品工业中被广泛应用。由于有一些关于八角对中枢神经系统（CNS）功能影响的数据，因此应该考虑其与作用于 CNS 的药物可能发生的相互作用。本研究旨在探讨八角精油（EO）摄入对作用于中枢神经系统的药物的影响。GC-MS 确定的精油化学特征表明，主要成分包括：反式茴香脑（88.49%）、γ-雪松烯（3.13%）、顺式异丁香酚（1.99%）和芳樟醇（1.79%）。在口服给予相当于人体等效剂量的八角 EO（0.3mg/kg）预处理 5 天后，在小鼠中测试了可待因、地西泮、咪达唑仑、戊巴比妥、丙咪嗪和氟西汀的作用。EO 的摄入导致可待因的镇痛作用显著增强。在 EO 处理的组中，咪达唑仑引起的运动障碍加剧。地西泮的应用降低了 EO 预处理组高架迷宫加测试中进入开放臂的次数和百分比，表明药物对运动活动的增强作用。与对照组相比，戊巴比妥诱导的睡眠时间明显缩短。与单独使用相比，丙咪嗪和氟西汀的抗抑郁作用减少，这是由于使用了八角 EO 预处理。基于这项研究的结果，我们得出结论，由于潜在的草药-药物相互作用，应避免同时摄入八角 EO 制剂和作用于 CNS 的药物，这也需要进一步的临床证实。
