Bhave Sanjay L, Teknos Theodoras N, Pan Quintin
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Columbus OH 43210, USA.
Crit Rev Eukaryot Gene Expr. 2011;21(2):143-53. doi: 10.1615/critreveukargeneexpr.v21.i2.40.
Metastasis remains a major cause of mortality in patients with head and neck squamous cell carcinoma (HNSCC). HNSCC patients with metastatic disease have extremely poor prognoses, with an average survival rate of less than a year. Metastasis is an intricate sequential process that requires a discrete population of tumor cells to possess the capacity to intravasate from the primary tumor into systemic circulation, survive in circulation, extravasate at a distant site, and proliferate in a foreign, hostile environment. Literature has accumulated to provide mechanistic insight into several signal transduction pathways, receptor tyrosine kinases (RTKs), signal transducer and activator of transcription 3 (Stat3), Rho GTPases, protein kinase Cε (PKCsε), and nuclear factor-κB (NF-κB), that are involved in mediating a metastatic tumor cell phenotype in HN-SCC. Herein we highlight accrued information regarding the key molecular parameters of HNSCC metastasis.
转移仍然是头颈部鳞状细胞癌（HNSCC）患者死亡的主要原因。患有转移性疾病的HNSCC患者预后极差，平均生存率不到一年。转移是一个复杂的连续过程，需要离散的肿瘤细胞群体具备从原发性肿瘤进入体循环、在循环中存活、在远处部位外渗并在陌生、恶劣环境中增殖的能力。已有文献积累，为深入了解几种信号转导通路、受体酪氨酸激酶（RTK）、信号转导和转录激活因子3（Stat3）、Rho GTP酶、蛋白激酶Cε（PKCsε）和核因子κB（NF-κB）提供了机制性见解，这些通路参与介导HN-SCC中的转移性肿瘤细胞表型。在此，我们重点介绍有关HNSCC转移关键分子参数的累积信息。
