Wesley Neurology Clinic, Memphis, TN, USA.
Headache. 2012 Mar;52(3):363-73. doi: 10.1111/j.1526-4610.2011.02029.x. Epub 2011 Nov 11.
The objective of this study is to investigate migraines, both longitudinally and cross-sectionally, to understand the impact that time of treatment has on migraine duration and the patients' return to daily functioning.
Several studies have explored the relationship between migraine treatment and its impact on migraine duration; however, the interrelationship of migraine onset and impact of treatment timing on migraine resolution is not completely understood.
DESIGN/METHODS: Five hundred and nine migraineurs completed 1 online baseline survey and a diary survey after each of their next 3 migraines. All subjects were 18 or older and were employed full time.
Migraine episodes treated within 1 hour were significantly shorter on average than those treated after 1 hour (9.1 hours vs 12.3 hours) (P < .05). Over-the-counter medication was the most frequently reported first-line treatment (44%) followed by an oral triptan (30%), another prescription medication (14%), and combination therapy (4%). Rescue treatment was reported in 57% of attacks. The majority of over-the-counter (69%) and another prescription (55%) treated attacks required rescue whereas only 39% of first-line triptan attacks required rescue.
Treating migraines early with an oral triptan-containing therapy appears to be a very effective method for reducing migraine duration and preventing the need for additional medication. Our findings also suggest that physicians should spend more time educating patients how to identify migraines early. Understanding the relationship between these key factors will provide insight into appropriate treatment and management of migraines, and more importantly, equip patients with the tools necessary to improve their outcomes and overall impact on functioning.
本研究旨在从纵向和横向两个方面探讨偏头痛，以了解治疗时机对偏头痛持续时间和患者恢复日常功能的影响。
已有多项研究探讨了偏头痛治疗与偏头痛持续时间之间的关系；然而，偏头痛发作的相互关系以及治疗时机对偏头痛缓解的影响尚不完全清楚。
设计/方法：509 名偏头痛患者完成了 1 次在线基线调查，并在接下来的 3 次偏头痛发作后每次完成 1 次日记调查。所有受试者年龄均在 18 岁及以上，且全职工作。
偏头痛发作在 1 小时内接受治疗的平均时间明显短于 1 小时后接受治疗的时间（9.1 小时 vs 12.3 小时）（P <.05）。非处方药物是最常报告的一线治疗方法（44%），其次是口服曲坦类药物（30%）、另一种处方药物（14%）和联合治疗（4%）。57%的发作需要进行急救治疗。大多数非处方（69%）和另一种处方（55%）治疗的发作需要急救，而只有 39%的一线曲坦类药物发作需要急救。
早期使用含有口服曲坦类药物的治疗方法治疗偏头痛似乎是一种非常有效的方法，可以缩短偏头痛持续时间，防止需要额外的药物治疗。我们的研究结果还表明，医生应该花更多的时间教育患者如何早期识别偏头痛。了解这些关键因素之间的关系将为偏头痛的适当治疗和管理提供深入了解，更重要的是，为患者提供改善治疗结果和整体功能影响所需的工具。
